In collaboration with BioRender, Akiko Iwasaki, Ph.D., Professor of Immunobiology at Yale University School of Medicine, explores COVID-19 Immunology 101 for Non-immunologists.
The immune system protects the host from invading pathogens through 2 layers: the innate and adaptive immunity. Innate immunity acts within minutes to remove the pathogen. Adaptive immunity takes days/wks but is specific & long lived, and is the basis for vaccines.
Innate immunity starts by triggering sensors that detect unusual molecules or activities, known as pattern recognition. Once microbial patterns are detected by these sensors (PRR), they trigger immediate alarm through secretion of cytokines and interferons.